ConsHMM Atlas

ConsHMM Atlas - Conservation state annotations for major genomes and human genetic variation

The ConsHMM Atlas provides an atlas of over twenty genome-wide ConsHMM conservation state annotations for 8 organisms. ConsHMM annotates reference genomes at single nucleotide resolution into different conservation states based on the combinatorial and spatial patterns within a multiple species alignment inferred using a multivariate Hidden Markov Model (HMM). ConsHMM can also produce allele specific conservation state annotations, which are provided as part of the ConsHMM Atlas for all possible single-nucleotide mutations in the human genome. Additionally, the ConsHMM Atlas provides visualization tools of model parameters and enrichments.

Access the main ConsHMM Atlas website Citation:
Arneson A, Ernst J. Systematic discovery of conservation states for single-nucleotide annotation of the human genome. Communications Biology, 2,248(2019).